Thyroid Function and Thyroglobulin Level in Iodine-Deficient Children of Eastern Nepal

Iodine deficiency during childhood affects physical and mental development. or excess both can negatively impact thyroid function. We conducted this study to assess iodine nutrition function in children with insufficient urinary concentration. A community-based cross-sectional was among the selected schools of Udayapur district. Urinary concentration (UIC) measured 1012 school (6-14 years). Based on UIC data, 83 blood samples were collected measure serum thyroglobulin (Tg), thyroid-stimulating hormone (TSH), free triiodothyronine (fT3), thyroxine (fT4). by ammonium persulfate digestion method, Tg, TSH, fT4, fT3 using ELISA kits. The median UIE 236 µg/L, 11.1% had UIC. mean fT3, TSH 2.55±0.43 pg/mL, 0.96±0.28 ng/dL, 3.60±1.44 mIU/L respectively. Among low levels, Tg 17.5 ng/mL. Overt hypothyroidism seen 6%, subclinical 3.6%. sufficient nutrition, frequency dysfunction